To address this gap, we examined QoL among cancer patients with comorbidities in Armenia and explored how these individuals manage their health and psychosocial well-being. We conducted a mixed-methods study at the Haematology Centre in Yerevan, Armenia, from January 2020 to September 2022. The study involved a survey administered to 82 cancer patients with doctor-confirmed comorbidities, conducted via telephone interviews. We assessed various health domains, including physical, cognitive, mental, social, pain interference, and fatigue. Additionally, we carried out semi-structured face-to-face interviews with a purposively selected group of 10 cancer patients (8 women) to gain deeper insights.

The results indicated that the majority of participants were men (68%, average age 62.7 years), married (78%), and retired (56.1%). Many reported difficulties in daily activities, such as performing chores (41.5%), running errands and shopping (39%), going for walks (29.6%), and engaging in leisure activities (36.6%). Cognitive challenges were also prevalent, with about one in five participants feeling fearful (19.7%), uneasy (24.4%), or anxious (16%). A pervasive sense of fatigue was noted, with nearly 50% reporting that pain interfered with their daily activities and household tasks. Key themes identified through the interviews included symptom experiences, treatment burden, and financial distress.

In conclusion, it is essential that assessments of cancer patients adopt a whole-person approach, prioritizing the impact of comorbidities on their physical, mental, and social functioning, as well as financial well-being. To support these patients effectively, multicomponent targeted interventions and tailored support services must be developed to address their individual needs and priorities, promoting and sustaining their health and well-being.